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Alzheimer's Disease Research
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Alzheimer's Disease Research - Current Awards
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Paul Axelsen, M.D.
University of Pennsylvania
Philadelphia, PA
Title: Oxidative stress and amyloidogenesis
Non-Technical Title: The chemistry of Alzheimer's disease
Duration: April 1, 2008 - March 31, 2009
Award Type: Pilot
$150,000 |
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Oxidative stress and amyloid fibril formation are consistent major themes among processes thought to be involved in the pathogenesis of Alzheimer's disease. However, a mechanistic link between these two processes has not been defined. The research being proposed will probe human brain tissues and animal models of Alzheimer's disease for evidence of a specific chemical mechanism that will be amenable to therapeutic intervention.
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Randall Bateman, M.D.
Washington University
St. Louis, MO
Title: Human CNS-Apolipoprotein E Isoform Production and Clearance
Non-Technical Title: Metabolism of the protein (ApoE) that increases risk of Alzheimer's Disease in humans.
Duration: April 1, 2008 - March 31, 2010
Award Type: Pilot
$150,000 |
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Although te ApoE is the strongest genetic risk factor for Alzheimer's disease, relatively little is known about the how ApoE contributes to that risk. This study seeks to characterize basic biological differences between three different ApoE alleles.
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Gal Bitan, Ph.D.
University of California, Los Angeles
Los Angeles, CA
Title: [Information embargoed while investigator completes patent application]
Non-Technical Title: [Information embargoed while investigator completes patent application]
Duration: April 1, 2008 - March 31, 2010
Award Type: Standard
$100,000 |
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[Information embargoed while investigator completes patent application]
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Guojun Bu, Ph.D.
Washington University
St. Louis, MO
Title: Modulation of APP Trafficking and Abeta Production
Non-Technical Title:
Duration: April 1, 2006 - March 31, 2008
Award Type: Standard
$300,000 |
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Barbara Calabrese, Ph.D.
University of California, San Diego
La Jolla, CA
Title: Rapid Effects of Soluble AB on Synaptic Structure
Non-Technical Title: Determining the effect of ABeta on neronal cells
Duration: April 1, 2007 - March 31, 2009
Award Type: Research Fellowship
$100,000 |
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Dr. Calabrese hypothesizes that exposure of neurons to low levels of soluble ABeta results in definable changes in the numbers, shape, and stability of synapses. Pharmacological and gene transfer manipulations of synaptic ABeta targets will be used in combination with high resolution live cell imaging to test this hypothesis.
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Anne Cataldo, Ph.D.
McLean Hospital
Belmont, MA
Title: A Novel Treatment Strategy for Neurorepair in Alzheimer's Disease
Non-Technical Title: The Use of Adult Bone Marrow Stem Cells in Treating Alzheimer's Disease
Duration: April 1, 2008 - March 31, 2010
Award Type: Pilot
$150,000 |
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In this project, 'adult' stem cells will be used as a delivery system to deliver sAPP to brain regions undergoing neurodegeneration. The hypothesis is that sAPP will work together with growth factors to protect and repair cholinergic neurons in the brain, thereby representing a potential for therapeutic treatment in humans with AD.
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Robert Clark, Ph.D.
Meharry Medical College
Nashville, TN
Title: A Genetic Search for PresenilinInteractin Genes
Non-Technical Title:
Duration: April 1, 1999 - March 31, 2000
Award Type: Standard
$200,000 |
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David Cribbs, Ph.D.
Regents of the Univ. of California
Irvine, CA
Title: CNS Delivery of Immunotherapy Using MSCs
Non-Technical Title:
Acknowledgements: This project was funded by the Revocable Trust of Margery de Scheweinitz, deceased. ADR 2006
Duration: April 1, 2006 - March 31, 2008
Award Type: Standard
$300,000 |
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Luciano Domenici, M.D., Ph.D.
National Council of Research (C.N.R.)
Pisa, Italy
Title: RAGE, MAP kinases and Abeta induced synaptic dysfunction
Non-Technical Title: Role of RAGE in Alzheimer's disease
Duration: April 1, 2008 - March 31, 2010
Award Type: Pilot
$148,000 |
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Nerve signaling dysfunctions triggered by ABeta are central to AD progression. This study will lead to a better understanding of these processes, in particular, RAGE signaling. Results of this study will facilitate design of therapeutic agents that prevent or minimize the actions of ABeta on nerve signaling.
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James Foskett, Ph.D.
University of Pennsylvania
Philadelphia, PA
Title: IP3R-Presenilin Interaction: Calcium Dysregulation in AD
Non-Technical Title: Calcium disruption in Alzheimer's Disease
Duration: April 1, 2008 - March 31, 2011
Award Type: Standard
$400,000 |
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This study is designed to test how presenilin interacts with calcium signaling proteins, resulting in changes to the presenilin function. The study will also examine how altered calcium signaling in turn affects other cell functions. These studies should provide new insights into the molecular mechanisms of AD and into the development of novel targets for therapeutic interventions.
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Last Reviewed On: 11/21/08
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